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Download PDF by Khalid Iqbal (Editor), Sangram S. Sisodia (Editor), Bengt: Alzheimer's Disease: Advances in Etiology, Pathogenesis and

By Khalid Iqbal (Editor), Sangram S. Sisodia (Editor), Bengt Winblad (Editor)

ISBN-10: 0470851740

ISBN-13: 9780470851746

ISBN-10: 0471521760

ISBN-13: 9780471521761

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Additional resources for Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics

Example text

1989). 1). Today we often diagnose clinical AD and dementia in less impaired individuals with a fair degree of accuracy. Can this be done in the briefer evaluations required for epidemiological studies? Inclusion of cases of dementia at a very early stage in the course of the illness is now recognized as important, but raises the issue of the accuracy of diagnoses in very mild dementia and also the issue of the accuracy of the differential diagnosis in dementia in the setting of an epidemiological study, where autopsy follow-up is unlikely.

Numerous investigations are based on 2–4 years of follow-up. Few studies have explored a longer period, and even fewer reports tried to characterize the nature of the differences in cognitive performance between preclinical AD and non-demented subjects. Finally, only one study described the course of cognitive deficits in the preclinical TRANSITION FROM NORMALITY TO DEMENTIA 5 phase of AD. The main findings from these three research lines will be discussed here. COGNITIVE DEFICITS 2–4 YEARS BEFORE AD DIAGNOSIS All studies consistently report a clear lowering of cognitive performance among incident AD cases some years before actual diagnosis.

His experience in the early 1970s as a clinician working with xxxii SCIENTISTS HONORED FOR PIONEERING RESEARCH older individuals with dementia, confirmed in his mind the frequency of AD in the elderly. In 1976 he marshaled evidence that AD was the fourth most common cause of death in the USA. His editorial on this topic led to the first NIH-sponsored symposium on AD in 1977, chaired by Drs Katzman, Terry and Bick. In 1979, as an investigator and as a family member, he helped found the Alzheimer Disease and Related Disorders Association (now the Alzheimer’s Association), co-chaired its first Scientific Advisory Board and participated in the 1984 NINCDS/ADRDA consensus conference on diagnostic criteria for AD.

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Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics by Khalid Iqbal (Editor), Sangram S. Sisodia (Editor), Bengt Winblad (Editor)


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