By Khalid Iqbal (Editor), Sangram S. Sisodia (Editor), Bengt Winblad (Editor)
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Additional resources for Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics
1989). 1). Today we often diagnose clinical AD and dementia in less impaired individuals with a fair degree of accuracy. Can this be done in the briefer evaluations required for epidemiological studies? Inclusion of cases of dementia at a very early stage in the course of the illness is now recognized as important, but raises the issue of the accuracy of diagnoses in very mild dementia and also the issue of the accuracy of the differential diagnosis in dementia in the setting of an epidemiological study, where autopsy follow-up is unlikely.
Numerous investigations are based on 2–4 years of follow-up. Few studies have explored a longer period, and even fewer reports tried to characterize the nature of the differences in cognitive performance between preclinical AD and non-demented subjects. Finally, only one study described the course of cognitive deﬁcits in the preclinical TRANSITION FROM NORMALITY TO DEMENTIA 5 phase of AD. The main ﬁndings from these three research lines will be discussed here. COGNITIVE DEFICITS 2–4 YEARS BEFORE AD DIAGNOSIS All studies consistently report a clear lowering of cognitive performance among incident AD cases some years before actual diagnosis.
His experience in the early 1970s as a clinician working with xxxii SCIENTISTS HONORED FOR PIONEERING RESEARCH older individuals with dementia, conﬁrmed in his mind the frequency of AD in the elderly. In 1976 he marshaled evidence that AD was the fourth most common cause of death in the USA. His editorial on this topic led to the ﬁrst NIH-sponsored symposium on AD in 1977, chaired by Drs Katzman, Terry and Bick. In 1979, as an investigator and as a family member, he helped found the Alzheimer Disease and Related Disorders Association (now the Alzheimer’s Association), co-chaired its ﬁrst Scientiﬁc Advisory Board and participated in the 1984 NINCDS/ADRDA consensus conference on diagnostic criteria for AD.
Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics by Khalid Iqbal (Editor), Sangram S. Sisodia (Editor), Bengt Winblad (Editor)