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Advances in Research and Applications by G.D. Aurbach (Eds.) PDF

By G.D. Aurbach (Eds.)

ISBN-10: 0080866395

ISBN-13: 9780080866390

ISBN-10: 0080866417

ISBN-13: 9780080866413

ISBN-10: 0080866425

ISBN-13: 9780080866420

ISBN-10: 0127098429

ISBN-13: 9780127098425

ISBN-10: 0127098445

ISBN-13: 9780127098449

ISBN-10: 0127098453

ISBN-13: 9780127098456

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The enhanced preference for sweet taste has also been demonstrated by Sclafani (1978) and can be used as a test for assessing the effectiveness of the hypothalamic lesion. Whether this is a taste aversion or a metabolic response to absorbed quinine is unclear. Dehydroepiandrosterone, as another dietary additive, produces aversion and can reduce the body weight of rats with parasaggital hypothalamic knife cuts (Gosnell, 1987). Whether this steroid, normally produced by the adrenal, acts by blocking endogenous corticosterone effects or through other mechanisms is currently unknown.

1961). Dilution of the diet with cellulose, on the other hand, may not do so (Bray and York, 1972). , 1982). The role of hepatic signals has not been adequately examined. From the information available, it would appear that afferent signals are distorted from the oropharyngeal cavity and may play a role in the positive and negative finickiness and hyperphagia of animals with medial hypothalamic lesions. However, Cox and Powley (1981) have demonstrated that disturbances in the cephalic phase are not essential for the development of obesity in animals with VMH lesions.

1969; Atkinson and Brent, 1982; Koopmans, 1985) have been implicated in regulation of nutrient stores. The glucose concentration in rats with EXPERIMENTAL OBESITY 19 hypothalamic obesity may be low initially (Smith and Campfield, 1986). Changes in glucose may be a signal for initiation of a meal. Campfield et al. (1985) have shown that a 15%drop in glucose followed by a rise toward baseline is the signal for a meal in more than 60% of these transitions in glucose. In rats with VMH lesions the onset of meals may be delayed, but when they occur they are larger than in control rats.

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Advances in Research and Applications by G.D. Aurbach (Eds.)


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